---
title: "DIPEA: research glossary | Sable Peptides"
description: "N,N-Diisopropylethylamine (DIPEA), also called Hünig's base, is a sterically hindered tertiary amine used as a non-nucleophilic base in peptide coupling re"
canonical: https://www.sablepeptides.co.uk/glossary/dipea
publisher: Sable Peptides Limited (UK company 17488610)
note: Research use only. Not for human or veterinary use.
---

Glossary

# DIPEA

N,N-Diisopropylethylamine (DIPEA), also called Hünig's base, is a sterically hindered tertiary amine used as a non-nucleophilic base in peptide coupling reactions with uronium and phosphonium reagents. Its bulk prevents it from reacting with activated esters while it neutralises acids generated during coupling.

Source: [en.wikipedia.org](https://en.wikipedia.org/wiki/N,N-Diisopropylethylamine)

## Related terms

-   [Peptide](/glossary/peptide)

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