---
title: "Dimethylformamide: research glossary | Sable Peptides"
description: "Dimethylformamide (DMF) is a polar aprotic solvent widely used in solid-phase peptide synthesis for washing, Fmoc deprotection and coupling reactions becau"
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publisher: Sable Peptides Limited (UK company 17488610)
note: Research use only. Not for human or veterinary use.
---

Glossary

# Dimethylformamide

Dimethylformamide (DMF) is a polar aprotic solvent widely used in solid-phase peptide synthesis for washing, Fmoc deprotection and coupling reactions because it swells resins and dissolves protected amino acids well. It is classified as a reproductive toxicant, prompting interest in greener alternative solvents.

Source: [en.wikipedia.org](https://en.wikipedia.org/wiki/Dimethylformamide)

## Related terms

-   [Peptide](/glossary/peptide)
-   [Solid-phase peptide synthesis](/glossary/solid-phase-peptide-synthesis)

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