---
title: "Diisopropylcarbodiimide: research glossary | Sable Peptides"
description: "N,N'-Diisopropylcarbodiimide (DIC) is a carbodiimide coupling reagent used in peptide synthesis. Unlike DCC, its urea by-product is soluble in common solve"
canonical: https://www.sablepeptides.co.uk/glossary/diisopropylcarbodiimide
publisher: Sable Peptides Limited (UK company 17488610)
note: Research use only. Not for human or veterinary use.
---

Glossary

# Diisopropylcarbodiimide

N,N'-Diisopropylcarbodiimide (DIC) is a carbodiimide coupling reagent used in peptide synthesis. Unlike DCC, its urea by-product is soluble in common solvents, which suits solid-phase methods. DIC is typically used with additives such as Oxyma Pure or HOBt to increase efficiency and suppress racemisation.

Source: [en.wikipedia.org](https://en.wikipedia.org/wiki/N,N'-Diisopropylcarbodiimide)

## Related terms

-   [Peptide](/glossary/peptide)
-   [Coupling reagent](/glossary/coupling-reagent)
-   [Racemisation](/glossary/racemisation)
-   [Oxyma](/glossary/oxyma)

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