---
title: "Deamidation: research glossary | Sable Peptides"
description: "Deamidation is a chemical reaction in which the side-chain amide of asparagine or glutamine is removed, converting it to aspartic acid, isoaspartic acid or"
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---

Glossary

# Deamidation

Deamidation is a chemical reaction in which the side-chain amide of asparagine or glutamine is removed, converting it to aspartic acid, isoaspartic acid or glutamic acid. It increases mass by about 0.98 Da and introduces a negative charge. Deamidation is accelerated at neutral to alkaline pH and elevated temperature, especially at Asn-Gly sequences.

Source: [en.wikipedia.org](https://en.wikipedia.org/wiki/Deamidation)

## Related terms

-   [Asparagine](/glossary/asparagine)
-   [Glutamine](/glossary/glutamine)
-   [Aspartic acid](/glossary/aspartic-acid)
-   [Glutamic acid](/glossary/glutamic-acid)

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