---
title: "Cyclic peptide: research glossary | Sable Peptides"
description: "A cyclic peptide is a peptide whose chain forms a ring, either through a head-to-tail amide bond, a side-chain linkage, or a disulfide bridge. Cyclisation"
canonical: https://www.sablepeptides.co.uk/glossary/cyclic-peptide
publisher: Sable Peptides Limited (UK company 17488610)
note: Research use only. Not for human or veterinary use.
---

Glossary

# Cyclic peptide

A cyclic peptide is a peptide whose chain forms a ring, either through a head-to-tail amide bond, a side-chain linkage, or a disulfide bridge. Cyclisation restricts flexibility, which often increases resistance to proteolytic enzymes and can improve binding selectivity in research assays. Cyclic peptides are prepared synthetically by on-resin or solution-phase ring-closure reactions.

Source: [en.wikipedia.org](https://en.wikipedia.org/wiki/Cyclic_peptide)

## Related terms

-   [Peptide](/glossary/peptide)
-   [Resin](/glossary/resin)

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