---
title: "Coupling reagent: research glossary | Sable Peptides"
description: "A coupling reagent activates the carboxyl group of an amino acid so that it reacts efficiently with the free amine on the growing peptide chain. Common exa"
canonical: https://www.sablepeptides.co.uk/glossary/coupling-reagent
publisher: Sable Peptides Limited (UK company 17488610)
note: Research use only. Not for human or veterinary use.
---

Glossary

# Coupling reagent

A coupling reagent activates the carboxyl group of an amino acid so that it reacts efficiently with the free amine on the growing peptide chain. Common examples include carbodiimides such as DIC, often used with additives like Oxyma or HOBt, and uronium or phosphonium salts such as HBTU, HATU and PyBOP. Good coupling minimises racemisation and deletion sequences.

Source: [en.wikipedia.org](https://en.wikipedia.org/wiki/Peptide_synthesis)

## Related terms

-   [Peptide](/glossary/peptide)
-   [Amino acid](/glossary/amino-acid)
-   [Racemisation](/glossary/racemisation)
-   [Oxyma](/glossary/oxyma)

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