---
title: "C-terminus: research glossary | Sable Peptides"
description: "The C-terminus is the end of a peptide or protein chain bearing a free carboxyl group. Sequences are written ending at the C-terminus. Many synthetic resea"
canonical: https://www.sablepeptides.co.uk/glossary/c-terminus
publisher: Sable Peptides Limited (UK company 17488610)
note: Research use only. Not for human or veterinary use.
---

Glossary

# C-terminus

The C-terminus is the end of a peptide or protein chain bearing a free carboxyl group. Sequences are written ending at the C-terminus. Many synthetic research peptides are C-terminally amidated, replacing the carboxylic acid with a carboxamide; this removes a negative charge and alters the molecular weight by about one dalton compared with the free acid form.

Source: [en.wikipedia.org](https://en.wikipedia.org/wiki/C-terminus)

## Related terms

-   [Peptide](/glossary/peptide)
-   [Molecular weight](/glossary/molecular-weight)
-   [Dalton](/glossary/dalton)

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