---
title: "Boc: research glossary | Sable Peptides"
description: "Boc (tert-butyloxycarbonyl) is an acid-labile protecting group for amines. In Boc solid-phase peptide synthesis it is removed with trifluoroacetic acid at"
canonical: https://www.sablepeptides.co.uk/glossary/boc
publisher: Sable Peptides Limited (UK company 17488610)
note: Research use only. Not for human or veterinary use.
---

Glossary

# Boc

Boc (tert-butyloxycarbonyl) is an acid-labile protecting group for amines. In Boc solid-phase peptide synthesis it is removed with trifluoroacetic acid at each cycle, and the final cleavage from the resin traditionally uses very strong acids such as hydrogen fluoride. Boc chemistry has largely been replaced by Fmoc chemistry for routine synthesis but remains useful for difficult sequences.

Source: [en.wikipedia.org](https://en.wikipedia.org/wiki/Tert-Butyloxycarbonyl_protecting_group)

## Related terms

-   [Peptide](/glossary/peptide)
-   [Solid-phase peptide synthesis](/glossary/solid-phase-peptide-synthesis)
-   [Protecting group](/glossary/protecting-group)
-   [Resin](/glossary/resin)
-   [Cleavage](/glossary/cleavage)
-   [Trifluoroacetic acid](/glossary/trifluoroacetic-acid)

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