---
title: "Aspartimide formation: research glossary | Sable Peptides"
description: "Aspartimide formation is a side reaction in Fmoc peptide synthesis in which an aspartic acid side chain cyclises onto the backbone amide nitrogen, forming"
canonical: https://www.sablepeptides.co.uk/glossary/aspartimide-formation
publisher: Sable Peptides Limited (UK company 17488610)
note: Research use only. Not for human or veterinary use.
---

Glossary

# Aspartimide formation

Aspartimide formation is a side reaction in Fmoc peptide synthesis in which an aspartic acid side chain cyclises onto the backbone amide nitrogen, forming a five-membered succinimide ring. It is favoured by exposure to base and sequences such as Asp-Gly. Ring opening yields alpha- and beta-aspartyl peptides and racemised products, complicating purification.

Source: [pmc.ncbi.nlm.nih.gov](https://pmc.ncbi.nlm.nih.gov/articles/PMC12447389/)

## Related terms

-   [Peptide](/glossary/peptide)
-   [Aspartic acid](/glossary/aspartic-acid)

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