---
title: "Amidation: research glossary | Sable Peptides"
description: "C-terminal amidation is a modification in which the terminal carboxylic acid of a peptide is replaced by a carboxamide group. It occurs naturally in many p"
canonical: https://www.sablepeptides.co.uk/glossary/amidation
publisher: Sable Peptides Limited (UK company 17488610)
note: Research use only. Not for human or veterinary use.
---

Glossary

# Amidation

C-terminal amidation is a modification in which the terminal carboxylic acid of a peptide is replaced by a carboxamide group. It occurs naturally in many peptide hormones and is reproduced synthetically by using an amide-generating resin such as Rink amide. Amidation removes a negative charge, often increases resistance to carboxypeptidases, and lowers the mass by roughly 0.98 Da.

Source: [en.wikipedia.org](https://en.wikipedia.org/wiki/Amidation)

## Related terms

-   [Peptide](/glossary/peptide)
-   [Resin](/glossary/resin)

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