---
title: "Acetonitrile: research glossary | Sable Peptides"
description: "Acetonitrile (CH3CN) is a polar aprotic solvent and the most common organic modifier in reversed-phase HPLC of peptides. Its low viscosity and UV transpare"
canonical: https://www.sablepeptides.co.uk/glossary/acetonitrile
publisher: Sable Peptides Limited (UK company 17488610)
note: Research use only. Not for human or veterinary use.
---

Glossary

# Acetonitrile

Acetonitrile (CH3CN) is a polar aprotic solvent and the most common organic modifier in reversed-phase HPLC of peptides. Its low viscosity and UV transparency at low wavelengths make it well suited to gradient separations monitored at 214 to 220 nm. Small amounts can also help dissolve hydrophobic peptides.

Source: [en.wikipedia.org](https://en.wikipedia.org/wiki/Acetonitrile)

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