---
title: "2-Chlorotrityl chloride resin: research glossary | Sable Peptides"
description: "2-Chlorotrityl chloride resin is a highly acid-sensitive solid support used in Fmoc peptide synthesis. Peptides can be cleaved under very mild acidic condi"
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publisher: Sable Peptides Limited (UK company 17488610)
note: Research use only. Not for human or veterinary use.
---

Glossary

# 2-Chlorotrityl chloride resin

2-Chlorotrityl chloride resin is a highly acid-sensitive solid support used in Fmoc peptide synthesis. Peptides can be cleaved under very mild acidic conditions, such as dilute acetic acid or hexafluoroisopropanol in dichloromethane, while side-chain protecting groups stay intact, enabling synthesis of protected fragments for later condensation.

Source: [en.wikipedia.org](https://en.wikipedia.org/wiki/Peptide_synthesis)

## Related terms

-   [Peptide](/glossary/peptide)
-   [Resin](/glossary/resin)
-   [Acetic acid](/glossary/acetic-acid)
-   [Dichloromethane](/glossary/dichloromethane)

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