Technical notes

Last reviewed: 10 October 2026 · Sable Peptides research team

Long-form, sourced notes on peptide analysis, quality and materials science. Research use only.

• What independent quality-control studies have found in research-grade synthetic peptides

  Published laboratory studies have tested synthetic peptides bought for research and compared the results with suppliers' certificates.

  Last reviewed: 10 October 2026

• Lyophilised cake appearance: what freeze-drying leaves in the vial and why it varies

  Freeze-drying leaves a porous solid whose shape reflects how the solution froze and dried.

  Last reviewed: 10 October 2026

• Orthogonal identity testing for peptides: mass spectrometry, MS/MS, amino-acid analysis and NMR

  An intact-mass measurement by electrospray mass spectrometry confirms that the main component has the expected molecular mass.

  Last reviewed: 10 October 2026

• Peak purity and co-elution: what a single HPLC purity figure can and cannot tell you

  An HPLC purity figure is the main peak's share of the total UV peak area under one set of chromatographic conditions.

  Last reviewed: 10 October 2026

• Stereochemistry in research peptides: D-residues, racemisation and isoaspartate

  Every standard amino acid except glycine is chiral and exists as L- and D-forms of identical mass.

  Last reviewed: 10 October 2026

• How metrology institutes assign purity to peptide reference materials

  National metrology institutes that certify peptide reference materials don't rely on one HPLC number.

  Last reviewed: 10 October 2026

• Capillary electrophoresis for peptides: an orthogonal check on purity, counter-ions and stereochemistry

  Capillary electrophoresis separates charged molecules by how fast they migrate in an electric field.

  Last reviewed: 10 October 2026

• Peptide adsorption to container surfaces: what analytical studies have measured

  Peptides can stick to the walls of glass and plastic containers, pipette tips and instrument tubing.

  Last reviewed: 10 October 2026

• Water, the glass transition and solid-state stability of lyophilised peptides

  A lyophilised peptide is usually an amorphous, glass-like solid.

  Last reviewed: 10 October 2026

• Degradation impurity profiles: what stressed-storage studies reveal about peptide breakdown products

  When peptides degrade, they form a predictable family of breakdown products.

  Last reviewed: 10 October 2026

Research use only. Not for human consumption. No health claims.